Assessment of Circuit Rebreathing During Continuous Positive Airway Pressure (CPAP) Therapy
Status: Recruiting
Location: See location...
Intervention Type: Device, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 70
Healthy Volunteers: f
View:
• Moderate to severe OSA (AHI\>20)
• Self-reported CPAP users or have previously used CPAP
• Self-reported holding pressure of maximum 13 cmH2O (if known)
• Age: 21-70
• BMI: 18-40 kg/m2
Locations
United States
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Contact Information
Primary
Atqiya Aishah, PhD
aaishah@bwh.harvard.edu
857 396 3808
Backup
Scott A Sands, PhD
sasands@bwh.harvard.edu
6172780911
Time Frame
Start Date: 2025-05-27
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 13
Treatments
Experimental: 5 cmH2O with 35L/s
35 L/s exhaust flow with 5 cmH₂O PAP
Experimental: 5 cmH2O with 23L/s
23 L/s exhaust flow with 5 cmH₂O PAP
Experimental: 5 cmH2O with 18L/s
18 L/s exhaust flow with 5 cmH₂O PAP
Experimental: 5 cmH2O with 13L/s
13 L/s exhaust flow with 5 cmH₂O PAP
Experimental: 5 cmH2O with 8L/s
8 L/s exhaust flow with 5 cmH₂O PAP
Placebo_comparator: 0 cmH2O with 35L/s
35 L/s exhaust flow with 0 cmH₂O PAP
Experimental: 10 cmH2O with 35L/s
35 L/s exhaust flow with 10 cmH₂O PAP
Experimental: 10 cmH2O with 23L/s
23 L/s exhaust flow with 10 cmH₂O PAP
Experimental: 10 cmH2O with 18L/s
18 L/s exhaust flow with 10 cmH₂O PAP
Experimental: 10 cmH2O with 13L/s
13 L/s exhaust flow with 10 cmH₂O PAP
Experimental: 10 cmH2O with 8L/s
8 L/s exhaust flow with 10 cmH₂O PAP
Related Therapeutic Areas
Sponsors
Leads: Brigham and Women's Hospital
Collaborators: Sleep Res, Inc.